The Reventon is powered by a 6.5 litre V12 engine that delivers 650 HP (478 kW) at 8,000 revolutions per minute (rpm). The huge torque, equal to maximum 660 Nm, ensures a powerful switch from any number of revolutions: even the slightest pressure on the accelerator is spontaneously transformed into thrust.

As in the original Murciélago LP640, the Reventon accelerates from 0 to 100 km/h in just 3.4 seconds, with a maximum speed over 340 km/h.